Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.

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Article

Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.

Molecular vision - 1 Jan 2012

Shukla Navika D, Tiwari Vaibhav, Valyi-Nagy Tibor

Abstract excerpt

PURPOSE: Primary and recurrent infections of the cornea by herpes simplex virus 1 (HSV-1) are important causes of eye disease. Three unrelated classes of glycoprotein D receptors for HSV-1 entry into cells have been identified. This study was undertaken to uncover the relative significance of nectin-1 as an entry receptor in corneal infection and HSV-1 spread to the trigeminal ganglia (TG), a site important for...

Topics

Animals
Cell Adhesion Molecules
Disease Models, Animal
Epithelium, Corneal
Gene Expression
Herpes Simplex
Herpesvirus 1, Human
Humans
Immunohistochemistry
Keratitis, Herpetic
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mutation

Nectins

Real-Time Polymerase Chain Reaction

Receptors, Virus

Trigeminal Ganglion

Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 23213272
PMCID: PMC3513192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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