Article
Somatic mutation theory.
Journal of toxicology and environmental health - 1 Jan 2000
Sorsa M
Abstract excerpt
The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for atherosclerosis, to neurological deterioration, and to senescence of...
Topics
- Aging
- DNA Repair
- Embryo, Mammalian
- Female
- Humans
- Mutation
- Neoplasms
- Pregnancy