Article
DNA-repair deficiencies do not affect intercalator-induced cytotoxicity or DNA scission in human cells.
Mutation research - 1 Jan 2000
Zwelling L A, Mattern M R
Abstract excerpt
The ability of the DNA intercalator m-AMSA to produce protein-associated DNA-strand breaks in normal, xeroderma pigmentosum and ataxia-telangiectasia fibroblasts was compared with m-AMSA uptake and cytotoxicity. No differences were detected between the cytotoxicity and DNA breakage produced by this antineoplastic acridine derivative among these three human cell lines. Uptake studies confirmed that no actual...
Topics
- Aminoacridines
- Amsacrine
- Ataxia Telangiectasia
- Biological Transport
- Cell Line
- Cell Survival
- DNA Repair
- Fibroblasts
- Humans
- Intercalating Agents
- Kinetics
- Mutation