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Assessing the impact of different solvents in the bacterial reverse mutation test.

Environmental and molecular mutagenesis - 1 Jan 2025

Patel Satyam N, Kajavadara Chetan K, Shukla Rushikesh M, Valani Darshan T, Bhatt Laxit K, Sundar Rajesh, Jain Mukul R

Abstract excerpt

The bacterial reverse mutation test is essential for identifying the mutagenic potential of chemicals. The solubility of the test substance is vital for achieving the recommended assay concentration. Preferred solvents like dimethyl sulfoxide and water are chosen for their compatibility and historical data. Selecting a compatible solvent with Salmonella typhimurium and Escherichia coli WP2 uvrA strains,...

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PMID: 39803708
DOI: 10.1002/em.22649

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