[Isolation and characteristics of a mutant herpes simplex virus type 1 resistant to phosphonoacetic acid].

Article

[Isolation and characteristics of a mutant herpes simplex virus type 1 resistant to phosphonoacetic acid].

Voprosy virusologii - 1 Jan 2000

Gibadulin R A, Denisova T S, Zavgorodniĭ S G, Florent'ev V L, Zhdanov V M

Abstract excerpt

By successive passages and triple cloning of herpes simplex virus type 1 (HSV-1) in Vero cell culture in the presence of increasing concentrations of phosphonoacetic acid (PAA) a mutant of HSV-1 resistant to PAA (PAAr) was derived and characterized. The resistance to the inhibitor was transmitted...

Topics

DNA, Viral
Drug Resistance, Microbial
Genetic Markers
Mutation
Organophosphorus Compounds
Phosphonoacetic Acid
Recombination, Genetic
Simplexvirus
Virus Cultivation

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