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Article

Cell-selfish modes of evolution and mutations directed after transcriptional bypass.

Mutation research - 29 Dec 2002

Holmquist Gerald P

Abstract excerpt

During transcription, prokaryotic and eukaryotic RNA polymerases bypass and misread (transcriptional mutagenesis) several classes of DNA lesions. For example, misreading of 8-OH-dG generates mRNAs containing G to T transversions. After translation, if the mutant protein briefly allowed the cell a growth-DNA replication advantage, then precocious DNA replication would bypass that unrepaired 8-OH-dG and misinsert...

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PMID: 12459450
DOI: 10.1016/s0027-5107(02)00259-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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