Article
Interleukin-3 supports growth of mouse pre-B-cell clones in vitro.
Nature - 1 Jan 2000
Palacios R, Henson G, Steinmetz M, McKearn J P
Abstract excerpt
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture...
Topics
- Animals
- Antigens, Surface
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Clone Cells
- DNA Replication
- Epitopes
- Genes
- Immunoglobulin M
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Interleukin-3
- Lymphocyte Activation
- Lymphokines
- Mice
- Mice, Nude
- Phenotype