Lag-induced critical transitions to extinction in replicating systems: the τ-tipping mechanism.

Abstract excerpt

Replicating systems sustained by error-prone enzymatic amplification can undergo critical transitions between persistence and extinction. In RNA viruses, such transitions are classically governed by mutation rates and fitness landscape topographies, giving rise to error thresholds and lethal mutagenesis. Motivated by experimental evidence that polymerase-targeting antivirals limit replication, we analyze...

Topics

• Virus Replication
• Mutation
• RNA Viruses
• Time Factors
• RNA Replication
• Models, Biological
• Models, Genetic