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Article

The paradoxical dynamics of prion disease latency.

Journal of theoretical biology - 21 Apr 1998

Payne R J, Krakauer D C

Abstract excerpt

A salient characteristic of the prion diseases--including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy in cattle--is an extended asymptomatic incubation period followed by a rapid and often fatal clinical phase. We present a kinetic model of progression of infection based upon the existence of a bottleneck in the natural protein pathways within the cell. The model can reconcile the different...

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Identifiers

PMID: 9631573
DOI: 10.1006/jtbi.1997.0627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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