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Article

Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit/hyperactivity disorder.

Addiction biology - 1 Jul 2016

Groenman Annabeth P, Greven Corina U, van Donkelaar Marjolein M J, Schellekens Arnt, van Hulzen Kimm J E, Rommelse Nanda, Hartman Catharina A, Hoekstra Pieter J, Luman Marjolein, Franke Barbara, Faraone Stephen V, Oosterlaan Jaap, Buitelaar Jan K

Abstract excerpt

Individuals with attention deficit/hyperactivity disorder (ADHD) are at increased risk of developing substance use disorders (SUDs) and nicotine dependence. The co-occurrence of ADHD and SUDs/nicotine dependence may in part be mediated by shared genetic liability. Several neurobiological pathways have been implicated in both ADHD and SUDs, including dopamine and serotonin pathways. We hypothesized that variations...

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Identifiers

PMID: 25752199
DOI: 10.1111/adb.12230
PMCID: PMC4561224

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