Adherence to antiretroviral therapy and drug resistance impact evolving viral suppression among a cohort of children and adolescents living with perinatal HIV infection in western Kenya.

doi:10.1371/journal.pone.0355492

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Adherence to antiretroviral therapy and drug resistance impact evolving viral suppression among a cohort of children and adolescents living with perinatal HIV infection in western Kenya.

PloS one - 1 Jan 2026

Vreeman Rachel, Nyandiko Winstone, DeLong Allison, Chory Ashley, Scanlon Michael, Aluoch Josephine, Sang Edwin, Novitsky Vladimir, Sang Festus, Ashimosi Celestine, Ayaya Samuel, Jepkemboi Eslyne, Orido Millicent, Hogan Joseph, Kantor Rami

Abstract excerpt

BACKGROUND: We characterize antiretroviral therapy (ART) adherence among children and adolescents living with perinatal HIV (CALWH) and investigate its impact on treatment failure (TF) and drug resistance (DR). METHODS: We enrolled Kenyan CALWH ≤15 years on NNRTI-based ART and monitored adherence over six months, with monthly, validated questionnaires and continuous MEMs (Medication Event Monitoring Systems)...

Read the complete abstract on PubMed

Topics

Humans
Female
Kenya
HIV Infections
Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

Adolescent

Viral Load

Anti-HIV Agents

Male

HIV-1

Mutation

Child, Preschool

Cohort Studies

Drug Monitoring

Source

Open in PubMed Open full text

Identifiers

PMID: 42743304
DOI: 10.1371/journal.pone.0355492
PMCID: PMC13577498

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adherence to antiretroviral therapy and drug resistance impact evolving viral suppression among a cohort of children and adolescents living with perinatal HIV infection in western Kenya.PMID 42743304Read ↗

Prevalence of Pre-antiretroviral-Treatment Drug Resistance by Gender, Age, and Other Factors in HIV-Infected Individuals Initiating Therapy in Kenya, 2013-2014.Semantic proximity Read ↗

Clinical, Psychosocial, and Structural Factors Associated with the Detection of HIV Drug Resistance in Children Living with HIV in Kisumu, Kenya: Secondary Analysis of Data from the Opt4Kids Study.Semantic proximity Read ↗

Added Value of Next Generation Sequencing in Characterizing the Evolution of HIV-1 Drug Resistance in Kenyan Youth.Semantic proximity Read ↗

Human Immunodeficiency Virus (HIV) Drug Resistance in African Infants and Young Children Newly Diagnosed With HIV: A Multicountry Analysis.Semantic proximity Read ↗

Drug Resistance Among Adolescents and Young Adults with Virologic Failure of First-Line Antiretroviral Therapy and Response to Second-Line Treatment.Semantic proximity Read ↗

HIV viral non-suppression and drug resistance among persons who inject drugs on dolutegravir antiretroviral therapy in KenyaSemantic proximity Read ↗

HIV Drug Resistance Patterns and Characteristics Associated with Clinically Significant Drug Resistance among Children with Virologic Failure on Antiretroviral Treatment in Kenya: Findings from the Opt4Kids Randomized Controlled TrialSemantic proximity Read ↗

Longitudinal Analysis of Viral Suppression Before, During, and After Pregnancy Among Women on Antiretroviral Therapy in Uganda: Six-year Real-World EvidenceSemantic proximity Read ↗

Development of antiretroviral resistance in children with HIV in low- and middle-income countries.Semantic proximity Read ↗

Point-of-care HIV viral load and targeted drug resistance mutation testing versus standard care for Kenyan children on antiretroviral therapy (Opt4Kids): an open-label, randomised controlled trial.Semantic proximity Read ↗

Factors Associated With Viral Suppression and Drug Resistance in Children and Adolescents Living With HIV in Care and Treatment Programs in Southern TanzaniaSemantic proximity Read ↗

Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.