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Article

Metabolic phenotype dimensions and longitudinal renal function in type 2 diabetes: a principal component analysis-based approach with UACR integration.

Frontiers in endocrinology - 1 Jan 2026

Mei Caixia, Li Yang, Ma Hailin, Li Xueling, Jiang Sheng

Abstract excerpt

Background: Type 2 diabetes (T2D) exhibits substantial phenotypic heterogeneity, yet the relationship between multidimensional metabolic phenotypes and longitudinal renal function decline remains poorly characterized, particularly regarding albuminuria status. Objective: To identify metabolic phenotype dimensions using principal component analysis (PCA) in a Chinese T2D cohort and evaluate their associations with...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Male
Female
Albuminuria
Glomerular Filtration Rate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Principal Component Analysis

Retrospective Studies

Phenotype

Middle Aged

Creatinine

Diabetic Nephropathies

Longitudinal Studies

Aged

Kidney

Source

Open in PubMed Open full text

Identifiers

PMID: 42741563
DOI: 10.3389/fendo.2026.1929060
PMCID: PMC13572980

Genes

TG

Provenance

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