Article
SLE-Associated rs2295613(A) Allele Strengthens a Predicted c-MYC Motif and Enhances SLAMF1 Promoter Reporter Activity in B Cells.
Cells - 28 Aug 2026
Uvarova Aksinya N, Putlyaeva Lidia V, Korneev Kirill V, Stasevich Ekaterina M, Prikhodko Elvina A, Murashko Matvey M, Demin Denis E, Zheremyan Elina A, Schwartz Anton M, Kuprash Dmitry V
Abstract excerpt
SLAMF1 encodes CD150, an immunoregulatory receptor involved in lymphocyte activation, T-B-cell interactions, and humoral immune responses. The SLAMF1 promoter polymorphism rs2295613(G>A) was previously associated with systemic lupus erythematosus (SLE) susceptibility in a Chinese case-control cohort. Here, we investigated the regulatory activity of rs2295613 in the transformed B-cell lines Raji and MP1 and in...
Read the complete abstract on PubMed