Silencing of Kinesin Light Chain 1 Suppresses Aggressive Phenotypes in Cholangiocarcinoma Cells Through Transcriptomic Alterations.

doi:10.3390/ijms27177525

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Article

Silencing of Kinesin Light Chain 1 Suppresses Aggressive Phenotypes in Cholangiocarcinoma Cells Through Transcriptomic Alterations.

International journal of molecular sciences - 22 Aug 2026

Rattanaarchanai Thanakrit, Tantimetta Phonprapavee, Runsaeng Phanthipha, Saeheng Sompop, Obchoei Sumalee

Abstract excerpt

Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options and poor clinical outcomes. Kinesin light chain 1 (KLC1), a component of the kinesin-1 motor complex involved in intracellular transport, has been implicated in cancer biology; however, its role in CCA remains unclear. This study investigated the functional role and molecular alterations associated with KLC1 silencing in CCA....

Read the complete abstract on PubMed

Topics

Humans
Cholangiocarcinoma
Gene Expression Regulation, Neoplastic
Cell Line, Tumor
Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bile Duct Neoplasms

Cell Movement

Microtubule-Associated Proteins

Transcriptome

Phenotype

Gene Expression Profiling

Gene Silencing

Epithelial-Mesenchymal Transition

Protein Interaction Maps

Kinesins

Source

Open in PubMed Open full text

Identifiers

PMID: 42737429
DOI: 10.3390/ijms27177525
PMCID: PMC13566592

Genes

KLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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