Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations.

doi:10.1007/s12022-026-09934-y

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Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations.

Endocrine pathology - 12 Sept 2026

Vanoli Alessandro, Travaglino Erica, Inzani Frediano, Orione Tommaso, Grillo Federica, Parente Paola, Spaggiari Paola, Uccella Silvia, Zerbi Alessandro, Milanetto Anna Caterina, Lecca Mauro, Peri Andrea, Di Sabatino Antonio, Paulli Marco, La Rosa Stefano, Fassan Matteo, Errichiello Edoardo

Abstract excerpt

Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMSOM-NETs) remain poorly characterized. We performed an integrated morphological, immunohistochemical, and genomic analysis of a multicenter series of SAMSOM-NETs. Eleven cases were...

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Topics

Humans
Male
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neuroendocrine Tumors

Mutation

Common Bile Duct Neoplasms

Aged

Immunohistochemistry

Ampulla of Vater

Biomarkers, Tumor

Somatostatin

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 42730891
DOI: 10.1007/s12022-026-09934-y
PMCID: PMC13570915

Genes

HRAS
ARX
CDK12
CDX2
ISL1
KRAS
MUC1
NF1
NTRK3
PDX1
PRDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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