Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare, Yet Targetable: New Perspectives on Ampullary Carcinomas.

International journal of molecular sciences - 6 Feb 2026

Gutmans James, Friedlaender Alex, Mechahougui Hiba

Abstract excerpt

Ampullary carcinoma (AC) is a rare gastrointestinal malignancy with dual intestinal and pancreatobiliary differentiation, complicating diagnosis, staging, and treatment. This review synthesizes current epidemiology, pathology, and multi-omic data to outline a pragmatic care pathway: lineage-first at presentation, mutation-fast at progression. Histology remains the primary classifier: the intestinal subtype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to BRAF gene
Share to ERBB2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KRAS gene

Share to RET gene

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41684016
DOI: 10.3390/ijms27031597
PMCID: PMC12897727

Genes

BRAF
ERBB2
KRAS
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare, Yet Targetable: New Perspectives on Ampullary Carcinomas.PMID 41684016Read ↗

Molecular Targets and Therapies for Ampullary Cancer.Semantic proximity Read ↗

Advances in Molecular Pathology and Treatment of Periampullary Cancers.Semantic proximity Read ↗

Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.Semantic proximity Read ↗

Prevalence and spectrum of pathogenic germline variants in intestinal and pancreatobiliary type of ampullary cancer.Semantic proximity Read ↗

Ampullary carcinoma-A genetic perspective.Semantic proximity Read ↗

Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer CareSemantic proximity Read ↗

Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).Semantic proximity Read ↗

Identification and prevalence of potentially therapeutic targetable variants of major cancer driver genes in ampullary cancer patients in India through deep sequencing.Semantic proximity Read ↗

Gene Expression Profiling of Ampullary Carcinomas Classifies Ampullary Carcinomas into Biliary-Like and Intestinal-Like Subtypes That Are Prognostic of OutcomeSemantic proximity Read ↗

Phenotypic characterization and clinical outcome in ampullary adenocarcinoma.Semantic proximity Read ↗

Biliary tract cancers: advances in diagnostic and managementSemantic proximity Read ↗

Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.