Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres).

doi:10.1007/s12022-024-09826-z

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Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres).

Endocrine pathology - 1 Dec 2024

Mattiolo Paola, Bevere Michele, Mafficini Andrea, Verschuur Anna Vera D, Calicchia Martina, Hackeng Wenzel M, Simbolo Michele, Paiella Salvatore, Dreijerink Koen M A, Landoni Luca, Pedron Serena, Cingarlini Sara, Salvia Roberto, Milella Michele, Lawlor Rita T, Valk Gerlof D, Vriens Menno R, Scarpa Aldo, Brosens Lodewijk A, Luchini Claudio

Abstract excerpt

Glucagonomas are functioning pancreatic neuroendocrine tumors (PanNETs) responsible for glucagonoma syndrome. This study aims to shed light on the clinicopathological and molecular features of these neoplasms. Six patients with glucagonomas were identified. All neoplasms were investigated with immunohistochemistry for neuroendocrine markers (Synaptophysin, Chromogranin-A), ATRX, DAXX, ARX, and PDX1 transcription...

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PMID: 39331358
DOI: 10.1007/s12022-024-09826-z
PMCID: PMC11659356

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