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Article

Simulating the host niche: balancing complexity and control in the experimental evolution of antibiotic resistance and pathoadaptation.

Microbiology (Reading, England) - 1 Sept 2026

Hernandez-Bird Juan, Meirelles Lucas A

Abstract excerpt

The 'ESKAPE' pathogens cause the majority of antibiotic-resistant infections in humans, with associated mortality expected to surpass that of cancer by 2050. Outbreak strains of these pathogens often demonstrate a remarkable ability to establish infection and easily acquire novel antimicrobial resistance mechanisms. Because the expression of virulence factors and antimicrobial resistance genes often imposes a...

Read the complete abstract on PubMed

Topics

Humans
Anti-Bacterial Agents
Bacteria
Drug Resistance, Bacterial
Host-Pathogen Interactions
Bacterial Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Host Adaptation

Evolution, Molecular

Animals

Mutation

Virulence Factors

Adaptation, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 42726510
DOI: 10.1099/mic.0.001767
PMCID: PMC13567839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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