Association of DNMT3A Polymorphism, Oxidative Stress, and Global DNA Methylation in Type 2 Diabetes Mellitus Patients.

doi:10.33594/000000889

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Article

Association of DNMT3A Polymorphism, Oxidative Stress, and Global DNA Methylation in Type 2 Diabetes Mellitus Patients.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 11 Sept 2026

Allami Ali Majeed, Al-Musawi Hawraa Sabah, Mohammed Hiba Abdulameer, Amshawee Ahmed M, Hussain Maryam A, Alyasiri Thura, Al-Daraji Mohammed, Alazzawi Islam K, Al-Terehi Mona N, Hasan Ahmed Flayyih

Abstract excerpt

BACKGROUND/AIMS: DNA methylation is a critical epigenetic mechanism involved in the regulation of gene expression, including genes implicated in glucose metabolism. Despite growing evidence indicating that epigenetic mechanisms are involved in the pathogenesis and progression of type 2 diabetes mellitus (T2DM), available data remain limited. This study analyzed the genetic association of two single-nucleotide...

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Topics

Humans
Diabetes Mellitus, Type 2
Oxidative Stress
DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Methylation

DNA Methyltransferase 3A

Female

Polymorphism, Single Nucleotide

Male

Middle Aged

Case-Control Studies

Blood Glucose

Genotype

Insulin

Glycated Hemoglobin

Insulin Resistance

Source

Open in PubMed

Identifiers

PMID: 42725388
DOI: 10.33594/000000889

Genes

DNMT3A
TG

Provenance

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