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Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

15 Apr 2019

Abstract excerpt

Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral blood DNA remains to be elucidated. We collected fasting blood samples (104 patients and 108 healthy controls) and glucose-stimulated blood samples at different time points...

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PMID: 30987683
DOI: 10.1186/s13148-019-0660-y

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