Article
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell reports. Medicine - 21 May 2024
Liu Chang, Zhou Daming, Dijokaite-Guraliuc Aiste, Supasa Piyada, Duyvesteyn Helen M E, Ginn Helen M, Selvaraj Muneeswaran, Mentzer Alexander J, Das Raksha, de Silva Thushan I, Ritter Thomas G, Plowright Megan, Newman Thomas A H, Stafford Lizzie, Kronsteiner Barbara, Temperton Nigel, Lui Yuan, Fellermeyer Martin, Goulder Philip, Klenerman Paul, Dunachie Susanna J, Barton Michael I, Kutuzov Mikhail A, Dushek Omer, Fry Elizabeth E, Mongkolsapaya Juthathip, Ren Jingshan, Stuart David I, Screaton Gavin R
Abstract excerpt
BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the...
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