Complementation of a human disease phenotype by intercellular mRNA transfer.

Abstract excerpt

There is growing evidence that mRNAs undergo intercellular transfer through cytoplasmic connections called tunneling nanotubes (TNTs), but whether transferred mRNAs are translated and affect cellular changes post-transfer is unknown. Using multiple lines of evidence, we show that transferred mRNAs undergo translation and can complement the phenotype of genetic mutations in vitro. For example, the human peroxisome...

Topics

• Humans
• RNA, Messenger
• Phenotype
• Peroxisomes
• Zellweger Syndrome
• Fibroblasts
• RNA Transport