Article

Complementation of a human disease phenotype in vitro by intercellular mRNA transfer

2024-11-06

Abstract excerpt

There is growing evidence that full-length mRNAs undergo intercellular transfer through long, thin cytoplasmic connections called tunneling nanotubes (TNTs), but whether transferred mRNAs are translated and effect cellular changes post-transfer is unknown. Using multiple lines of evidence, we show that transferred mRNAs undergo translation and can fully complement the phenotype of genetic mutations in vitro . For...

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Literature Corpus work: 5fa4a033-5236-5f17-b57d-eddd2d3dc59e
DOI: 10.1101/2024.11.06.622258

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