Article
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
American journal of respiratory and critical care medicine - 1 Mar 2020
Allen Richard J, Guillen-Guio Beatriz, Oldham Justin M, Ma Shwu-Fan, Dressen Amy, Paynton Megan L, Kraven Luke M, Obeidat Ma'en, Li Xuan, Ng Michael, Braybrooke Rebecca, Molina-Molina Maria, Hobbs Brian D, Putman Rachel K, Sakornsakolpat Phuwanat, Booth Helen L, Fahy William A, Hart Simon P, Hill Mike R, Hirani Nik, Hubbard Richard B, McAnulty Robin J, Millar Ann B, Navaratnam Vidyia, Oballa Eunice, Parfrey Helen, Saini Gauri, Whyte Moira K B, Zhang Yingze, Kaminski Naftali, Adegunsoye Ayodeji, Strek Mary E, Neighbors Margaret, Sheng Xuting R, Gudmundsson Gunnar, Gudnason Vilmundur, Hatabu Hiroto, Lederer David J, Manichaikul Ani, Newell John D, O'Connor George T, Ortega Victor E, Xu Hanfei, Fingerlin Tasha E, Bossé Yohan, Hao Ke, Joubert Philippe, Nickle David C, Sin Don D, Timens Wim, Furniss Dominic, Morris Andrew P, Zondervan Krina T, Hall Ian P, Sayers Ian, Tobin Martin D, Maher Toby M, Cho Michael H, Hunninghake Gary M, Schwartz David A, Yaspan Brian L, Molyneaux Philip L, Flores Carlos, Noth Imre, Jenkins R Gisli, Wain Louise V
Abstract excerpt
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding of...
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