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Article

Unraveling causal links between chronic rhinosinusitis and peripheral artery diseases: insights from genetic correlations through genome-wide association studies.

Brazilian journal of otorhinolaryngology - 1 Jan 2026

Wei Bo, He Jiaoyu, Gan Weigang, Wang Binbin, Liu Feng

Abstract excerpt

OBJECTIVES: Chronic Rhinosinusitis (CRS) shares epidemiological links with Cardiovascular Diseases (CVDs), however, their shared genetic basis remains unclear. We hypothesized that pleiotropic genetic variants underlie CRS-CVDs links via distinct biological pathways. METHODS: Using large-scale GWAS data from European-ancestry individuals, we assessed global and local genetic correlations. We applied Genomic...

Read the complete abstract on PubMed

Topics

Humans
Rhinosinusitis
Genome-Wide Association Study
Chronic Disease
Peripheral Arterial Disease
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Mendelian Randomization Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42685396
DOI: 10.1016/j.bjorl.2026.101891
PMCID: PMC13563561

Genes

APOM
COL11A2

Provenance

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