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Speech-in-Noise Hearing Impairment and Incident Dementia: A UK Biobank Cohort Study Across Polygenic, APOE ε4, and Familial Risk Strata.

Alzheimer disease and associated disorders - 1 Jan 2026

Peng Cong, Gong Guoqing, Chen Zhetian, Wu Jingwei, Liu Dan, Chen Bin

Abstract excerpt

OBJECTIVE: Hearing impairment is considered an important modifiable risk factor for dementia, but whether its association with incident dementia is consistent across inherited susceptibility profiles remains unclear. METHODS: This prospective cohort study included 80,287 UK Biobank participants aged 40 to 69 years at baseline with valid Digit Triplet Test measurements, genetic data, linked follow-up data, and...

Read the complete abstract on PubMed

Topics

Humans
Dementia
United Kingdom
Female
Male
Apolipoprotein E4
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Risk Score

Middle Aged

Prospective Studies

Adult

Risk Factors

UK Biobank

Hearing Loss

Incidence

Genetic Predisposition to Disease

Cohort Studies

Biological Specimen Banks

Source

Identifiers

PMID: 42684102
DOI: 10.1097/WAD.0000000000000747

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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