Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and genetic features of Ph-negative myeloproliferative neoplasms with dual-driver gene positivity.

Hematology (Amsterdam, Netherlands) - 31 Dec 2026

Yang Yan, Guo Qunyi, Tung Tao-Hsin, Zhang Jia, Wang Yuanwen, Ying Shuangwei

Abstract excerpt

OBJECTIVES: To investigate the clinical laboratory characteristics and gene mutation features of dual-driver gene positivity in patients with Philadelphia chromosome-negative myeloproliferative neoplasm (Ph-negative MPN). METHODS: We conducted a retrospective analysis of clinical data and genetic test results from 203 newly diagnosed patients with Ph-negative MPN. Of these, 194 had single-driver gene positivity...

Read the complete abstract on PubMed

Topics

Humans
Female
Janus Kinase 2
Male
Myeloproliferative Disorders
Receptors, Thrombopoietin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Aged

Middle Aged

Calreticulin

Philadelphia Chromosome

Adult

Retrospective Studies

Aged, 80 and over

Source

Identifiers

PMID: 42678877
DOI: 10.1080/16078454.2026.2717810

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and genetic features of Ph-negative myeloproliferative neoplasms with dual-driver gene positivity.PMID 42678877Read ↗

[Clinical Analysis of Driver Mutations in Patients with Ph Negative Myeloproliferative Neoplasms].Semantic proximity Read ↗

Genetic and Clinical Characteristics of Patients with Philadelphia-Negative Myeloproliferative Neoplasm Carrying Concurrent Mutations in JAK2V617F, CALR, and MPL.Semantic proximity Read ↗

Clinical and biological characterization of MPN patients harboring two driver mutations, a F rench intergroup of myeloproliferative neoplasms (FIM) studySemantic proximity Read ↗

Analysis of Common Driver Mutations in Philadelphia-Negative Myeloproliferative Neoplasms.Semantic proximity Read ↗

Genetic basis and molecular profiling in myeloproliferative neoplasms.Semantic proximity Read ↗

Prevalence and clinicopathological features of driver gene mutations profile in BCR:ABL1 negative classical myeloproliferative neoplasm-A single-center study from North India.Semantic proximity Read ↗

Recent insights regarding the molecular basis of myeloproliferative neoplasms.Semantic proximity Read ↗

Non-MPL-W515K/L mutations in myeloproliferative neoplasms: Insights from two case reports and a review of the literature.Semantic proximity Read ↗

A Rare Case of Essential Thrombocythemia with Coexisting JAK2 and MPL Driver Mutations.Semantic proximity Read ↗

Ph-chromosome-negative myeloproliferative neoplasms: clonal dynamics are the name of the game.Semantic proximity Read ↗

Integration of Molecular Information in Risk Assessment of Patients with Myeloproliferative Neoplasms.Semantic proximity Read ↗

Clinical laboratory characteristics and gene mutation spectrum of Ph-negative MPN patients with atypical variants of JAK2, MPL, or CALR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.