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Article

Clinical and biological characterization of MPN patients harboring two driver mutations, a F rench intergroup of myeloproliferative neoplasms (FIM) study

21 Dec 2017

Abstract excerpt

Mutations in “driver” genes (JAK2, MPL, or CALR) are found in the vast majority of Philadelphia-negative myeloproliferative neoplasms (MPN): JAK2V617F or exon 12 mutations in polycythemia vera (PV), JAK2V617F, CALR exon 9, or MPL exon 10 mutations in essential thrombocythemia (ET) or primary myelofibrosis (PMF). In the latter, phenotypic presentation and evolutive course vary according to the mutation, eg, higher...

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PMID: 29266414
DOI: 10.1002/ajh.25014

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