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Article

Rational Design of a Dual Mutant Degrading Enzyme with Improved Catalytic Efficiency and Acid Tolerance for Four Aflatoxins.

Journal of agricultural and food chemistry - 26 Aug 2026

An Qi, Chen Qihang, Zhou Jingwen, Gao Song, Wang Jia-Sheng, Sun Xiulan

Abstract excerpt

Aflatoxins are major contaminants in raw food materials and their products. Developing enzymes that efficiently degrade multiple aflatoxins under acidic conditions has great practical value. In this study, the aflatoxin-degrading enzyme ADPPIII from Aspergillus terreus was systematically engineered. Substrate tunnel optimization obtained mutant F375L, which showed about twice the degradation activity for four...

Read the complete abstract on PubMed

Topics

Aflatoxins
Aspergillus
Fungal Proteins
Hydrogen-Ion Concentration
Protein Engineering
Substrate Specificity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biocatalysis

Kinetics

Mutation

Zea mays

Enzyme Stability

Source

Identifiers

PMID: 42677651
DOI: 10.1021/acs.jafc.6c03843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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