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Enhancing the Thermostability and Catalytic Activity of a Multicopper Oxidase from Bacillus megaterium for Aflatoxin B1 and Zearalenone Degradation.

Journal of agricultural and food chemistry - 13 May 2026

Zhang Hongxin, Zhang Shujie, Muzaffar Nazish, Logrieco Antonio Francesco, Mule Giuseppina, Yang Yuhui, Ma Weibin, Liang Yabo, Xie Yanli

Abstract excerpt

Mycotoxins are toxic secondary metabolites commonly found in cereal crops, posing significant health risks to humans and animals. In this study, a multicopper oxidase from Bacillus megaterium (BmCueO) has been identified as an effective catalyst for degrading Aflatoxin B1 (AFB1) and Zearalenone (ZEN). Through semi-rational design, a triple-point mutant (D373P/Q144Y/Q350F) was constructed to enhance its...

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PMID: 42047502
DOI: 10.1021/acs.jafc.6c03322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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