Small cell transformation in EGFR-mutated non-small cell lung cancer: DLL3 expression and efficacy of immune checkpoint inhibitors or tyrosine kinase inhibitors combined with chemotherapy.

doi:10.1016/j.ejca.2024.115065

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Article

Small cell transformation in EGFR-mutated non-small cell lung cancer: DLL3 expression and efficacy of immune checkpoint inhibitors or tyrosine kinase inhibitors combined with chemotherapy.

European journal of cancer (Oxford, England : 1990) - 1 Dec 2024

Saalfeld Felix Carl, Möller Johanna, Christopoulos Petros, Wenzel Carina, Rasokat Anna, Wang Xuejun Alice, Vathiotis Ioannis, König David, Illini Oliver, Grohé Christian, Wiesweg Marcel, Wesseler Claas, Schubart Christoph, Pelusi Natalie, Rohde Gernot, Overbeck Tobias R, Kirfel Jutta, Alt Jürgen, Kauffmann-Guerrero Diego, Griesinger Frank, Kulhavy Jonas, Allgäuer Michael, Klimova Anna, Schütz Maret, Aust Daniela E, Hochmair Maximilian J, Rothschild Sacha I, Syrigos Konstantinos N, Veluswamy Rajwanth, Michels Sebastian, Stenzinger Albrecht, Jöhrens Korinna, Wermke Martin

Abstract excerpt

INTRODUCTION: Small cell transformation (SCT) is a typical mechanism of adaptive resistance to third generation epidermal growth factor receptor inhibitors (EGFRi) which have become the standard of care for EGFR-driven non-small cell lung cancer (EGFR+ NSCLC). Little is known about the optimal management of SCT patients. This study aimed to compare outcomes under platinum/etoposide chemotherapy alone (chemo) or...

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PMID: 39423775
DOI: 10.1016/j.ejca.2024.115065

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