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Article

Age-Dependent and APOE-Modified Associations Between Vascular Risk Factor Patterns and Cognitive Function: A Latent Class Analysis of 44,879 NACC Participants.

Alzheimer disease and associated disorders - 1 Jan 2026

Kong Yan, Li Xian, Guan Ruiqian, Wang Xin, Chen Ao, Zhang Hongkun

Abstract excerpt

INTRODUCTION: Vascular risk factors (VRFs) are established contributors to cognitive decline, yet they often co-occur in distinct patterns. Whether VRF pattern-cognition associations are modified by age or apolipoprotein E (APOE) genotype remains unclear. METHODS: We analyzed 44,879 participants aged 60 to 90 years from the National Alzheimer's Coordinating Center (NACC) with normal cognition or mild cognitive...

Read the complete abstract on PubMed

Topics

Humans
Female
Aged
Male
Aged, 80 and over
Middle Aged
Latent Class Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cognitive Dysfunction

Cognition

Risk Factors

Apolipoprotein E4

Age Factors

Apolipoproteins E

Hypertension

Genotype

Source

Identifiers

PMID: 42663119
DOI: 10.1097/WAD.0000000000000739

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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