Ribonucleotide reductase repression: a mutational study of NrdR-binding motifs.

doi:10.1128/jb.00274-26

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Article

Ribonucleotide reductase repression: a mutational study of NrdR-binding motifs.

Journal of bacteriology - 17 Sept 2026

Shahid Saher, Lundin Daniel, Rozman Grinberg Inna, Sjöberg Britt-Marie

Abstract excerpt

The prevalent transcriptional repressor NrdR binds to highly conserved sequences in the promoter regions of prokaryotic operons encoding the essential enzyme ribonucleotide reductase. The NrdR-binding sites consist of two partially palindromic 16 bp sequences (NrdR boxes) separated by a 15-16 bp linker sequence. We have assessed the requirement of both boxes for binding, the propensity of different NrdRs to bind...

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Topics

Escherichia coli
Ribonucleotide Reductases
Binding Sites
Repressor Proteins
Streptomyces coelicolor
Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Bacterial

Promoter Regions, Genetic

Protein Binding

Base Sequence

DNA, Bacterial

Inverted Repeat Sequences

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42658101
DOI: 10.1128/jb.00274-26
PMCID: PMC13584703

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