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Article

DNA phosphorothioation in Streptomyces lividans: mutational analysis of the dnd locus.

BMC microbiology - 20 Feb 2009

Xu Tiegang, Liang Jingdan, Chen Shi, Wang Lianrong, He Xinyi, You Delin, Wang Zhijun, Li Aiying, Xu Zhongli, Zhou Xiufen, Deng Zixin

Abstract excerpt

BACKGROUND: A novel DNA phosphorothioate modification (DNA sulfur modification), in which one of the non-bridging oxygen atoms in the phosphodiester bond linking DNA nucleotides is exchanged by sulphur, was found to be genetically determined by dnd or dnd-counterpart loci in a wide spectrum of bacteria from diverse habitats. A detailed mutational analysis of the individual genes within the dnd locus in...

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PMID: 19232083
DOI: 10.1186/1471-2180-9-41
PMCID: PMC2653506

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