Article
Beyond complement: comprehensive assessment of factor XIII plasma dynamics and genetics in atypical hemolytic uremic syndrome.
Research and practice in thrombosis and haemostasis - 1 Jul 2026
Janszky Noémi, Katona Éva, Sinkovits György, Csuka Dorottya, Haris Ágnes, Tasic Velibor, Abazi-Emini Nora, Aigner Christof, Schmidt Alice, Sunder-Plassmann Gere, Bloudíčková Silvie Rajnochová, Prohászka Zoltán, Muszbek László, Szilágyi Ágnes
Abstract excerpt
Background: Atypical hemolytic uremic syndrome (aHUS) is a distinct form of thrombotic microangiopathy characterized by formation of fibrin-rich thrombi. Factor XIII (FXIII), a key fibrin-stabilizing enzyme, may therefore represent an unexplored contributor to the pathophysiology of aHUS, and a comprehensive evaluation of its plasma dynamics and genetic background is lacking. Objectives: This study aimed to...
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