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Hepatitis Delta Virus Clade 8 Is the Predominant Clade Circulating in Botswana amongst People Living with HIV.

Viruses - 4 Oct 2024

Baruti Kabo, Choga Wonderful T, Motshosi Patience C, Phinius Bonolo B, Phakedi Basetsana, Bhebhe Lynnette N, Mpebe Gorata G A, Tsayang Chanana D, Ratsoma Tsholofelo, Gaolathe Tendani, Mosepele Mosepele, Makhema Joseph, Shapiro Roger, Lockman Shahin, Moyo Sikhulile, Jongman Mosimanegape, Anderson Motswedi, Gaseitsiwe Simani

Abstract excerpt

Hepatitis delta virus (HDV) co-infections more often result in severe hepatitis compared to hepatitis B virus (HBV) infections alone. Despite a high HDV prevalence (7.1%), information regarding circulating HDV clades is very limited in Botswana. We extracted total nucleic acid from confirmed HDV-positive samples and quantified their viral load. We then sequenced the large hepatitis delta antigen (L-HDAg) using...

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Identifiers

PMID: 39459902
DOI: 10.3390/v16101568
PMCID: PMC11512356

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