Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

22 Jul 2022

Abstract excerpt

Niemann-Pick type C disease (NPCD) is a rare genetic syndrome characterized by cholesterol accumulation in multiple organelles. NPCD is mainly caused by gene deficiency of NPC intracellular cholesterol transporter 1 (NPC1). It has been reported that some of the NPCD patients exhibit clinical features of progressive hearing loss at high frequency and iron disorder, but the underlying relationship is unknown. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related molecular mechanisms research
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35936782
DOI: 10.3389/fmolb.2022.952608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory CellsPMID 35936782Read ↗

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticitySemantic proximity Read ↗

The Antioxidative Role of Autophagy in Hearing LossSemantic proximity Read ↗

Age-Related Hearing Loss in C57BL/6J Mice Is Associated with Mitophagy Impairment in the Central Auditory SystemSemantic proximity Read ↗

Auditory Phenotype of Niemann-Pick Disease, Type C1Semantic proximity Read ↗

Otoferlin: a multi-C2 domain protein essential for hearing.Semantic proximity Read ↗

OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin.Semantic proximity Read ↗

Crosstalk among TFEB, the autophagy lysosomal pathway and ROS derived from damaged mitochondria in NaAsO2-induced auditory senescent cellsSemantic proximity Read ↗

Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in miceSemantic proximity Read ↗

Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by inducing mitophagySemantic proximity Read ↗

Promoter polymorphism rs510432 in ATG5 affects the susceptibility of noise-induced hearing loss by altering the binding of C/EBPβ.Semantic proximity Read ↗

Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis.Semantic proximity Read ↗

Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.