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Article

Mendelian Randomization and Single-Cell Transcriptomic Analyses Implicate PPP1R1B as a Risk Factor of Intrahepatic Cholangiocarcinoma.

Genes - 25 Jul 2026

Chen Zhuomiaoyu, Cao Fumei, Li Zhao

Abstract excerpt

Background:PPP1R1B has been implicated in tumor progression in several malignancies; however, population-level genetic evidence supporting its role in intrahepatic cholangiocarcinoma (ICC) remains limited. This study aimed to investigate the association between PPP1R1B and ICC risk and prognosis using genetic and multi-omics analyses. Methods: Multiple public datasets were integrated, including...

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Identifiers

PMID: 42650061
DOI: 10.3390/genes17080868
PMCID: PMC13512375

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