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Article

Bidirectional Mendelian randomization analysis reveals significant associations between Serum DNA repair proteins and liver cancer.

Cancer biomarkers : section A of Disease markers - 1 Jan 2026

Lin Sihao, Fang Kunpeng, Geng Li

Abstract excerpt

PurposeThis study investigated causal relationships and underlying mechanisms between serum DNA repair proteins and liver cancer to identify biomarkers for clinical management.MethodsA two-sample bidirectional Mendelian randomization (MR) design was employed. We performed inverse variance weighted (IVW) analysis, followed by protein quantitative trait loci (pQTL), colocalization, and pathway enrichment analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42017899
DOI: 10.1177/18758592261429328

Genes

NBR1
PARP1
PARP11
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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