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Article

Untangling the causes of geographical disparities in the clinical outcome of HTLV-1 infection: a critical perspective on the contribution of viral genetic diversity.

Journal of virology - 19 Aug 2025

Duchateau Thomas, Afonso Philippe V, Journo Chloé

Abstract excerpt

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is the etiological agent of two major diseases, adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as various other inflammatory manifestations. The prevalence of HTLV-1 infection varies greatly from region to region, and available epidemiological data support the notion that even among regions...

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Identifiers

PMID: 40622170
DOI: 10.1128/jvi.00601-25
PMCID: PMC12363171

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