Article
Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.
Nature aging - 1 Sept 2026
Li Jiaming, Gao Dan-Dan, Li Jing, Cao Lei, Du Yuanyuan, Xiong Muzhao, Chu Xi, Lei Wan, Ye Wei-Dong, Xu Gang, Ma Lina, Tang Jiazhen, Fu Qing, Zheng Zikai, Zhao Hongkai, Yi Ming, Lan Chunyu, Xu Liu-Jun, Fan Yanling, Zhu Guohua, Xiao Liwen, Zheng Quan, Si Sicong, Cheng Huabiao, Jiang Beier, Sun Shuhui, Jiang Wenjian, Ma Shuai, Zhang Hongjia, Wang Si, Yang Yun-Gui, Yang Jiayin, Qu Jing, Zhang Feng, Liu Zhili, Zhao Guoguang, Liu Guang-Hui, Zhang Weiqi
Abstract excerpt
Aging is a primary risk factor for chronic diseases, yet its progression varies among individuals and between sexes. Here, under the X-Age Project, we profiled the clinical aging phenome of the Multicentric Chinese Aging Study (mCAS) through a cross-sectional analysis of 172 clinical measures from more than 100,000 participants aged 18-98 years across three centers. These profiles enabled sex-specific clinical...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Aging
- Aged