Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.

doi:10.1186/s13073-024-01403-7

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Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.

Genome medicine - 8 Nov 2024

Chen Li, Tan Karen Mei-Ling, Xu Jia, Mishra Priti, Mir Sartaj Ahmad, Gong Min, Narasimhan Kothandaraman, Ng Bryan, Lai Jun Shi, Tint Mya Thway, Cai Shirong, Sadananthan Suresh Anand, Michael Navin, Yaligar Jadegoud, Velan Sambasivam Sendhil, Leow Melvin Khee Shing, Tan Kok Hian, Chan Jerry, Meaney Michael J, Chan Shiao-Yng, Chong Yap Seng, Eriksson Johan G

Abstract excerpt

BACKGROUND: Phenotypic age (PhenoAge), a widely used marker of biological aging, has been shown to be a robust predictor of all-cause mortality and morbidity in different populations. Existing studies on biological aging have primarily focused on individual domains, resulting in a lack of a comprehensive understanding of the multi-systemic dysregulation that occurs in aging. METHODS: PhenoAge was evaluated based...

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PMID: 39516835
DOI: 10.1186/s13073-024-01403-7
PMCID: PMC11549770

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PC
ZDHHC19

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