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Article

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.

Endocrine pathology - 24 Aug 2026

Purnaghshband Helia, Tuzlali Elif, Deka Kamalika Bhandari, Bruce Jeffrey P, Farncombe Kirsten M, Gillies Brittany, Prokopec Stephenie D, Pugh Trevor, Redmond Sarah, Redondo Laura, Wang Hong, Ezzat Shereen, Mete Ozgur, Kim Raymond H

Abstract excerpt

Adrenal and extra-adrenal paragangliomas (PPGLs) are highly heritable non-epithelial neuroendocrine neoplasms. Through a retrospective chart review of 110 individuals diagnosed with PPGLs at the University Health Network in Toronto, Canada (2011-2023), we characterized germline findings, tumor features, self-reported ethnicity, and variant reclassification across a multi-ethnic cohort using targeted germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42635851
DOI: 10.1007/s12022-026-09930-2
PMCID: PMC13503469

Genes

PALB2
SDHA
SDHB
TSC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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