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Article

Next-generation sequencing for the diagnosis of hereditary pheochromocytoma and paraganglioma syndromes

14 Apr 2015

Abstract excerpt

PURPOSE OF REVIEW: About 40% of the neuroendocrine tumors pheochromocytomas and paragangliomas (PPGLs) are caused by an inherited mutation. Diagnostic genetic screening is recommended for patients and their families. However, the number of susceptibility genes involved is high and continues to grow, making conventional sequencing costly and burdensome. Next-generation sequencing (NGS) enables accurate, thorough,...

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PMID: 25871962
DOI: 10.1097/med.0000000000000150

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