Update on the genetics of paragangliomas.

Abstract excerpt

Paragangliomas (PGL) of the adrenal (also known as pheochromocytomas) or extra-adrenal neural crest-derived cells are highly heritable tumors, usually driven by single pathogenic variants that occur mutually exclusively in genes involved in multiple cellular processes, including the response to hypoxia, MAPK/ERK signaling, and WNT signaling. The discovery of driver mutations has led to active clinical...

Topics

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• Adrenal and Paraganglionic Tumors
• Adrenal Gland Neoplasms
• Cancer, Hypoxia, and Metabolism
• Hormonal Regulation and Hypertension
• Mutation