Article
Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages.
Journal of hematology & oncology - 4 May 2017
Yang Meng, Topaloglu Umit, Petty W Jeffrey, Pagni Matthew, Foley Kristie L, Grant Stefan C, Robinson Mac, Bitting Rhonda L, Thomas Alexandra, Alistar Angela T, Desnoyers Rodwige J, Goodman Michael, Albright Carol, Porosnicu Mercedes, Vatca Mihaela, Qasem Shadi A, DeYoung Barry, Kytola Ville, Nykter Matti, Chen Kexin, Levine Edward A, Staren Edgar D, D'Agostino Ralph B, Petro Robin M, Blackstock William, Powell Bayard L, Abraham Edward, Pasche Boris, Zhang Wei
Abstract excerpt
BACKGROUND: Solid tumors residing in tissues and organs leave footprints in circulation through circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA). Characterization of the ctDNA portraits and comparison with tumor DNA mutational portraits may reveal clinically actionable information on solid tumors that is traditionally achieved through more invasive approaches. METHODS: We isolated ctDNAs from...
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