The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.

doi:10.1007/s12031-020-01676-8

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The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.

Journal of molecular neuroscience : MN - 1 Mar 2021

Tippairote Torsak, Bjørklund Geir, Peana Massimiliano, Roytrakul Sittiruk

Abstract excerpt

The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages. We herein reported the findings of Thai family members who had the compound of uncommon HFE rs2794719, together with transferrin (TF) rs1867504, transferrin receptor 2 (TfR2) rs7385804, and...

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Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GPI-Linked Proteins

Hemochromatosis Protein

Hepcidins

Iron Overload

Motor Neuron Disease

Receptors, Transferrin

Transferrin

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PMID: 32895881
DOI: 10.1007/s12031-020-01676-8

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