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Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK

7 Apr 2025

Abstract excerpt

All positive-strand RNA viruses replicate their genomes in association with modified intracellular membranes, inducing either membrane invaginations termed spherules, or double-membrane vesicles. Alphaviruses encode four non-structural proteins nsP1-nsP4, all of which are essential for RNA replication and spherule formation. To understand the host factors associated with the replication complex, we fused the...

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PMID: 40193402
DOI: 10.1371/journal.ppat.1013050

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