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Article

Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.

Journal of virology - 9 Dec 2020

Lukash Tetyana, Agback Tatiana, Dominguez Francisco, Shiliaev Nikita, Meshram Chetan, Frolova Elena I, Agback Peter, Frolov Ilya

Abstract excerpt

Decades of insufficient control have resulted in unprecedented spread of chikungunya virus (CHIKV) around the globe, and millions have suffered from the highly debilitating disease. Nevertheless, the current understanding of CHIKV-host interactions and adaptability of the virus to replication in mosquitoes and mammalian hosts is still elusive. Our new study shows that four-and-a-half LIM domain protein (FHL1) is...

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Identifiers

PMID: 33055253
DOI: 10.1128/JVI.01672-20
PMCID: PMC7737738

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