Article
Diminished Pro-Inflammatory Characteristics in Murine Bone Marrow Derived Macrophages with Impaired Thyroid Hormone Receptor Alpha 1 Signaling.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2026
Hoen Esmée, Falize Kim, Jongejan Aldo, Cheng Sheue-Yann, Zhu Xu-Guang, Bruinstroop Eveline, van der Spek Anne H, Boelen Anita
Abstract excerpt
BACKGROUND: Macrophages are versatile phagocytes of the innate immune system with functions ranging from pro-inflammatory to immunomodulatory. Macrophages are receptive to signals from thyroid hormones (THs). Here, we studied the role of the TH receptor (TR)α1 in macrophage function. METHODS: Using wild type (WT) and transgenic mice with a mutation in the T3 binding domain of the TRα1 (TRα1PV), we generated bone...
Read the complete abstract on PubMedTopics
- Animals
- Thyroid Hormone Receptors alpha
- Macrophages
- Signal Transduction
- Mice